Jacob Iasha Sznajder, M.D.
Ernest S. Bazley Professor of Medicine
Chief, Division of Pulmonary and Critical Care Medicine
Medical School: Technion, Israel Institute of Technology, Haifa, Israel. 1978
Internship/Residency: Internal Medicine, Rambam Medical Center, Technion, Israel Institute of Technology, Haifa, Israel. 1979-82 Residency: Internal Medicine, Hillel Yaffe Memorial Governmental Hospital, Hadera, Israel. 1982-83 Fellowship: Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL. 1983-86 Dr. Sznajder’s major clinical interests are acute respiratory distress syndrome, mechanical ventilation-induced lung injury, alternative modes of mechanical ventilation, and cardiovascular management of acute respiratory failure. His research focuses on mediators and mechanisms of acute lung injury, mechanisms of lung edema clearance, regulation of Na,K-ATPase in the alveolar epithelium, signal transduction pathways of gene regulation, and gene transfer to the alveolar epithelium.
Selected Recent Publications: Chen Z, Krmar RT, Dada L, Efendiev R, Leibiger IB, Pedemonte CH, Katz AI, Sznajder JI, Bertorello AM.
GPCR- as well as ROS-dependent Phosphorylation of AP2{micro}2 is Essential for Na+,K+-ATPase Endocytosis.
Am J Respir Cell Mol Biol. 2006 Feb 23; [Epub ahead of print]
PMID: 16498080 [PubMed - as supplied by publisher]
Mutlu GM, Snyder C, Bellmeyer A, Wang H, Hawkins K, Soberanes S, Welch LC, Ghio AJ, Chandel NS, Kamp DW, Sznajder JI, Budinger GR.
Airborne Particulate Matter Inhibits Alveolar Fluid Reabsorption in Mice via Oxidant Generation.
Am J Respir Cell Mol Biol. 2006 Jan 26; [Epub ahead of print]
PMID: 16439801 [PubMed - as supplied by publisher]
Bertorello AM, Sznajder JI.
The dopamine paradox in lung and kidney epithelia: sharing the same target but operating different signaling networks.
Am J Respir Cell Mol Biol. 2005 Nov;33(5):432-7. Review.
PMID: 16234332 [PubMed - indexed for MEDLINE]
Jain M, Sznajder JI.
Effects of hypoxia on the alveolar epithelium.
Proc Am Thorac Soc. 2005;2(3):202-5. Review.
PMID: 16222038 [PubMed - indexed for MEDLINE]
Mutlu GM, Sznajder JI.
Mechanisms of pulmonary edema clearance.
Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L685-95. Review.
PMID: 16214819 [PubMed - indexed for MEDLINE]
Mutlu GM, Sznajder JI.
Pseudohypoxemia: interpretation of discrepancies between SaO(2) and SpO(2).
Tuberk Toraks. 2005;53(2):185-9. Review.
PMID: 16100658 [PubMed - indexed for MEDLINE]
Ridge KM, Linz L, Flitney FW, Kuczmarski ER, Chou YH, Omary MB, Sznajder JI, Goldman RD.
Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells.
J Biol Chem. 2005 Aug 26;280(34):30400-5. Epub 2005 Jun 22.
PMID: 15972820 [PubMed - indexed for MEDLINE]
Jones JC, Lane K, Hopkinson SB, Lecuona E, Geiger RC, Dean DA, Correa-Meyer E, Gonzales M, Campbell K, Sznajder JI, Budinger S.
Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism.
J Cell Sci. 2005 Jun 15;118(Pt 12):2557-66. Epub 2005 May 31.
PMID: 15928048 [PubMed - indexed for MEDLINE]
Budinger GR, Sznajder JI.
Clin Invest. 2005 Apr;115(4):828-30.
PMID: 15841170 [PubMed - indexed for MEDLINE]
Mutlu GM, Adir Y, Jameel M, Akhmedov AT, Welch L, Dumasius V, Meng FJ, Zabner J, Koenig C, Lewis ER, Balagani R, Traver G, Sznajder JI, Factor P.
Interdependency of beta-adrenergic receptors and CFTR in regulation of alveolar active Na+ transport. Circ Res. 2005 May 13;96(9):999-1005. Epub 2005 Mar 31.
PMID: 15802612 [PubMed - indexed for MEDLINE]
Myrianthefs PM, Briva A, Lecuona E, Dumasius V, Rutschman DH, Ridge KM, Baltopoulos GJ, Sznajder JI.
Hypocapnic but not metabolic alkalosis impairs alveolar fluid reabsorption.
Am J Respir Crit Care Med. 2005 Jun 1;171(11):1267-71. Epub 2005 Mar 11.
PMID: 15764729 [PubMed - indexed for MEDLINE]
Jain M, Sznajder JI.
Low tidal volume needs to be used in patients with acute respiratory distress syndrome.
Crit Care Med. 2005 Jan;33(1):239-40. No abstract available.
PMID: 15644681 [PubMed - indexed for MEDLINE]
Machado-Aranda D, Adir Y, Young JL, Briva A, Budinger GR, Yeldandi AV, Sznajder JI, Dean DA.
Gene transfer of the Na+,K+-ATPase beta1 subunit using electroporation increases lung liquid clearance.
Am J Respir Crit Care Med. 2005 Feb 1;171(3):204-11. Epub 2004 Oct 29.
PMID: 15516538 [PubMed - indexed for MEDLINE]
Azzam ZS, Adir Y, Crespo A, Comellas A, Lecuona E, Dada LA, Krivoy N, Rutschman DH, Sznajder JI, Ridge KM. Norepinephrine increases alveolar fluid reabsorption and Na,K-ATPase activity.
Am J Respir Crit Care Med. 2004 Oct 1;170(7):730-6. Epub 2004 Jul 15.
PMID: 15256395 [PubMed - indexed for MEDLINE]Mutlu GM, Sznajder JI.
beta(2)-Agonists for treatment of pulmonary edema: ready for clinical studies?
Crit Care Med. 2004 Jul;32(7):1607-8. No abstract available.
PMID: 15241111 [PubMed - indexed for MEDLINE] Adir Y, Azzam ZS, Lecuona E, Leal S, Pesce L, Dumasius V, Bertorello AM, Factor P, Young JB, Ridge KM, Sznajder JI.
Augmentation of endogenous dopamine production increases lung liquid clearance.
Am J Respir Crit Care Med. 2004 Mar 15;169(6):757-63. Epub 2003 Dec 30.
PMID: 14701706 [PubMed - indexed for MEDLINE] Lecuona E, Ridge K, Pesce L, Batlle D, Sznajder JI.
The GTP-binding protein RhoA mediates Na,K-ATPase exocytosis in alveolar epithelial cells.
Mol Biol Cell. 2003 Sep;14(9):3888-97. Epub 2003 Jul 11.
PMID: 12972572 [PubMed - indexed for MEDLINE] Adir Y, Factor P, Dumasius V, Ridge KM, Sznajder JI.
Na,K-ATPase gene transfer increases liquid clearance during ventilation-induced lung injury.
Am J Respir Crit Care Med. 2003 Dec 15;168(12):1445-8. Epub 2003 Aug 28.
PMID: 12947023 [PubMed - indexed for MEDLINE] Dada LA, Chandel NS, Ridge KM, Pedemonte C, Bertorello AM, Sznajder JI.
Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta.
J Clin Invest. 2003 Apr;111(7):1057-64.
PMID: 12671055 [PubMed - indexed for MEDLINE] Dada LA, Sznajder JI.
Mechanisms of pulmonary edema clearance during acute hypoxemic respiratory failure: role of the Na,K-ATPase.
Crit Care Med. 2003 Apr;31(4 Suppl):S248-52. Review.
PMID: 12682448 [PubMed - indexed for MEDLINE] Pesce L, Comellas A, Sznajder JI.
Beta-adrenergic agonists regulate Na-K-ATPase via p70S6k.
Am J Physiol Lung Cell Mol Physiol. 2003 Oct;285(4):L802-7. Epub 2003 Apr 18.
PMID: 12704019 [PubMed - indexed for MEDLINE] Bertorello AM, Komarova Y, Smith K, Leibiger IB, Efendiev R, Pedemonte CH, Borisy G, Sznajder JI.
Analysis of Na+,K+-ATPase motion and incorporation into the plasma membrane in response to G protein-coupled receptor signals in living cells.
Mol Biol Cell. 2003 Mar;14(3):1149-57.
PMID: 12631730 [PubMed - indexed for MEDLINE] Ridge KM, Olivera WG, Saldias F, Azzam Z, Horowitz S, Rutschman DH, Dumasius V, Factor P, Sznajder JI.
Alveolar type 1 cells express the alpha2 Na,K-ATPase, which contributes to lung liquid clearance.
Circ Res. 2003 Mar 7;92(4):453-60. Epub 2003 Jan 30.
PMID: 12600893 [PubMed - indexed for MEDLINE] Saldias FJ, Comellas AP, Pesce L, Lecuona E, Sznajder JI.
Dopamine increases lung liquid clearance during mechanical ventilation.
Am J Physiol Lung Cell Mol Physiol. 2002 Jul;283(1):L136-43.
PMID: 12060570 [PubMed - indexed for MEDLINE] Ridge KM, Dada L, Lecuona E, Bertorello AM, Katz AI, Mochly-Rosen D, Sznajder JI.
Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta.
Mol Biol Cell. 2002 Apr;13(4):1381-9.
PMID: 11950946 [PubMed - indexed for MEDLINE] Azzam ZS, Dumasius V, Saldias FJ, Adir Y, Sznajder JI, Factor P.
Na,K-ATPase overexpression improves alveolar fluid clearance in a rat model of elevated left atrial pressure.
Circulation. 2002 Jan 29;105(4):497-501.
PMID: 11815434 [PubMed - indexed for MEDLINE] Saldias FJ, Lecuona E, Comellas AP, Ridge KM, Sznajder JI.
Dopamine restores lung ability to clear edema in rats exposed to hyperoxia.
Am J Respir Crit Care Med. 1999 Feb;159(2):626-33.
PMID: 9927383 [PubMed - indexed for MEDLINE] Factor P, Saldias F, Ridge K, Dumasius V, Zabner J, Jaffe HA, Blanco G, Barnard M, Mercer R, Perrin R, Sznajder JI.
Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na,K-ATPase beta1 subunit gene.
J Clin Invest. 1998 Oct 1;102(7):1421-30.
PMID: 9769335 [PubMed - indexed for MEDLINE] Saldias F, Lecuona E, Friedman E, Barnard ML, Ridge KM, Sznajder JI.
Modulation of lung liquid clearance by isoproterenol in rat lungs.
Am J Physiol. 1998 May;274(5 Pt 1):L694-701.
PMID: 9612284 [PubMed - indexed for MEDLINE] Barnard ML, Olivera WG, Rutschman DM, Bertorello AM, Katz AI, Sznajder JI.
Dopamine stimulates sodium transport and liquid clearance in rat lung epithelium.
Am J Respir Crit Care Med. 1997 Sep;156(3 Pt 1):709-14.
PMID: 9309983 [PubMed - indexed for MEDLINE] |
